Hello packing cube! Where have you been all my life?  

Seriously, packing cubes can make all the difference. They keep you organized, compact and when Mr. / Ms. TSA pops your suitcase open, none of your stale skivvies will be doing a walk about on the TSA table.  
 
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Best advice I can offer is travel light, and one bag travel is the way to go for less stress on the mind and body. For someone with a moderate amount of anxiety, like myself, the less you have to keep track of the calmer and more enjoyable your travels will be.   
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